| Total | Matches | Wins | Draws | Losses | |||
|---|---|---|---|---|---|---|---|
| Total | 378 | 167 | (44%) | 80 | (21%) | 131 | (35%) |
| Home | 190 | 115 | (61%) | 40 | (21%) | 35 | (18%) |
| Away | 185 | 52 | (28%) | 38 | (21%) | 95 | (51%) |
| Neutral field | 3 | 0 | (0%) | 2 | (67%) | 1 | (33%) |
| Item | Competition | Home | Away | |
|---|---|---|---|---|
| Biggest home win | Copa Libertadores 1971 | Peñarol | 9-0 | The Strongest |
| Copa Libertadores 1970 | Peñarol | 11-2 | Valencia FC | |
| Biggest away win | Copa Libertadores 1963 | Everest Guayaquil | 0-5 | Peñarol |
| Worst away defeat | Copa Libertadores 2002 | Real Potosí | 6-1 | Peñarol |
| Copa Libertadores 2011 | LDU Quito | 5-0 | Peñarol | |
| Worst home defeat | Copa Libertadores 2012 | Peñarol | 0-4 | Atlético Nacional |
| Copa Libertadores 1996 | Peñarol | 1-5 | San Lorenzo | |
| Copa Libertadores 2016 | Peñarol | 0-4 | Atlético Nacional |
