| 2021/03/27 | Loyola Ramblers |  | 58-65 |  | Oregon State Beavers | ||||
| Baylor Bears |  | 62-51 |  | Villanova Wildcats | |||||
| Arkansas Razorbacks |  | 72-70 |  | Oral Roberts Golden Eagles | |||||
| 2021/03/28 | Houston Cougars |  | 62-46 |  | Syracuse Orange | ||||
| Gonzaga Bulldogs |  | 83-65 |  | Creighton Bluejays | |||||
| Michigan Wolverines |  | 76-58 |  | Florida State Seminoles | |||||
| 2021/03/29 | Alabama Crimson Tide |  | 78-88 |  | UCLA Bruins | ||||
| USC Trojans |  | 82-68 |  | Oregon Ducks |
| 2021/03/21 | Illinois Fighting Illini |  | 58-71 | | Loyola Ramblers | ||||
| Baylor Bears | | 76-63 |  | Wisconsin Badgers | |||||
| West Virginia Mountaineers |  | 72-75 | | Syracuse Orange | |||||
| Arkansas Razorbacks | | 68-66 |  | Texas Tech Red Raiders | |||||
| Houston Cougars | | 63-60 |  | Rutgers Scarlet Knights | |||||
| Florida Gators |  | 78-81 | | Oral Roberts Golden Eagles | |||||
| 2021/03/22 | Villanova Wildcats | | 84-61 |  | North Texas Mean Green | ||||
| Oklahoma State Cowboys |  | 70-80 | | Oregon State Beavers | |||||
| Iowa Hawkeyes |  | 80-95 | | Oregon Ducks | |||||
| Gonzaga Bulldogs | | 87-71 |  | Oklahoma Sooners | |||||
| UCLA Bruins | | 67-47 |  | ACU Wildcats | |||||
| Creighton Bluejays | | 72-58 |  | Ohio Bobcats | |||||
| Michigan Wolverines | | 86-78 |  | LSU Tigers | |||||
| Florida State Seminoles | | 71-53 |  | Colorado Buffaloes | |||||
| 2021/03/23 | Alabama Crimson Tide | | 96-77 |  | Maryland Terrapins | ||||
| Kansas Jayhawks |  | 51-85 | | USC Trojans |
| 2021/03/19 | Florida Gators | | 75-70 a.e.t. |  | Virginia Tech Hokies | ||||
| Arkansas Razorbacks | | 85-68 |  | Colgate Raiders | |||||
| Illinois Fighting Illini | | 78-49 |  | Drexel Dragons | |||||
| Texas Tech Red Raiders | | 65-53 |  | Utah State Aggies | |||||
| Ohio State Buckeyes |  | 72-75 a.e.t. | | Oral Roberts Golden Eagles | |||||
| Baylor Bears | | 79-55 |  | Hartford Hawks | |||||
| Loyola Ramblers | | 71-60 |  | Georgia Tech | |||||
| Tennessee Volunteers |  | 56-70 | | Oregon State Beavers | |||||
| Oklahoma State Cowboys | | 69-60 |  | Liberty Flames | |||||
| North Carolina Tar Heels |  | 62-85 | | Wisconsin Badgers | |||||
| Houston Cougars | | 87-56 |  | Cleveland State Vikings | |||||
| Purdue Boilermakers |  | 69-78 a.e.t. | | North Texas Mean Green | |||||
| 2021/03/20 | Clemson Tigers |  | 56-60 | | Rutgers Scarlet Knights | ||||
| San Diego Aztecs |  | 62-78 | | Syracuse Orange | |||||
| West Virginia Mountaineers | | 84-67 |  | Morehead State Eagles | |||||
| Villanova Wildcats | | 73-63 |  | Winthrop Eagles | |||||
| Colorado Buffaloes | | 96-73 |  | Georgetown Hoyas | |||||
| Florida State Seminoles | | 64-54 |  | UNCG Spartans | |||||
| Kansas Jayhawks | | 93-84 |  | Eastern Washington Eagles | |||||
| LSU Tigers | | 76-61 |  | St. Bonaventure Bonnies | |||||
| Michigan Wolverines | | 82-66 |  | Texas Southern Tigers | |||||
| Creighton Bluejays | | 63-62 |  | UCSB Gauchos | |||||
| Alabama Crimson Tide | | 68-55 |  | Iona Gaels | |||||
| USC Trojans | | 72-56 |  | Drake Bulldogs | |||||
| Iowa Hawkeyes | | 86-74 |  | Grand Canyon Antelopes | |||||
| UConn Huskies |  | 54-63 | | Maryland Terrapins | |||||
| Virginia Cavaliers |  | 58-62 | | Ohio Bobcats | |||||
| Oklahoma Sooners | | 72-68 |  | Missouri Tigers | |||||
| 2021/03/21 | Gonzaga Bulldogs | | 98-55 |  | Norfolk State Spartans | ||||
| Brigham Young |  | 62-73 | | UCLA Bruins | |||||
| Texas Longhorns |  | 52-53 | | ACU Wildcats | |||||
| Oregon Ducks | | DA |  | VCU Rams |
